Codexis Presentation: Advanced Ligation and Stereochemical Control for Scalable RNA Manufacturing

Wednesday, September 23, 2:40pm - 3:05pm (EDT)

Time shown in-04:00 America, New York

Keynote Presentation: Advanced Ligation and Stereochemical Control for Scalable RNA Manufacturing

RNAi innovators and manufacturers are increasingly adopting ligation-based approaches for siRNA production, driven by clear advantages in efficiency, scalability, and process simplicity relative to traditional solid-phase oligonucleotide synthesis. At the same time, the incorporation of phosphorothioate (PS) linkages—essential for therapeutic stability and efficacy—introduces diastereomeric complexity that challenges both manufacturing control and analytical characterization. In this presentation, we highlight how advances in sequential enzymatic fragment synthesis and ligation—core capabilities of Codexis’ ECO Synthesis® Manufacturing Platform—address these limitations. By combining biocatalytic innovation, process optimization, and machine learning–guided design, this approach enables control over PS diastereomeric composition while enhancing ligation efficiency and reproducibility. The result is a streamlined, scalable manufacturing strategy that improves downstream processing and delivers high-quality siRNA with superior consistency, purity, and performance.

RNA Leaders Technical Track
Wednesday, 23 September 2026 | 2:40pm - 3:05pm EST (Eastern Time, UTC-05:00)

Add to Calendar 2026/09/23 14:40:00 2026/09/23 15:05:00 America/New_York Codexis Presentation: Advanced Ligation and Stereochemical Control for Scalable RNA Manufacturing Keynote Presentation: Advanced Ligation and Stereochemical Control for Scalable RNA Manufacturing

RNAi innovators and manufacturers are increasingly adopting ligation-based approaches for siRNA production, driven by clear advantages in efficiency, scalability, and process simplicity relative to traditional solid-phase oligonucleotide synthesis. At the same time, the incorporation of phosphorothioate (PS) linkages—essential for therapeutic stability and efficacy—introduces diastereomeric complexity that challenges both manufacturing control and analytical characterization. In this presentation, we highlight how advances in sequential enzymatic fragment synthesis and ligation—core capabilities of Codexis’ ECO Synthesis® Manufacturing Platform—address these limitations. By combining biocatalytic innovation, process optimization, and machine learning–guided design, this approach enables control over PS diastereomeric composition while enhancing ligation efficiency and reproducibility. The result is a streamlined, scalable manufacturing strategy that improves downstream processing and delivers high-quality siRNA with superior consistency, purity, and performance.

RNA Leaders Technical Track
Wednesday, 23 September 2026 | 2:40pm - 3:05pm EST (Eastern Time, UTC-05:00) Hynes Convention Center false MM/DD/YYYY 30 OPAQUE atGLTaEHUzsoYVqHOmWp346434

Hynes Convention Center

Colleen Davey, colleen.davey@codexis.com

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